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Although, there has been some pricing erosion, roughly to in nephrology and about in oncology, we have maintained a price premium of the order of to to the first generation EPOs. We and the agency share the goal of ensuring that ESAs are used appropriately and wish to make certain that both physicians and patients are well informed about the risks and benefits of ESA therapy, especially in the Cum shot induced anemia setting. Slide shows that we’ve have completed the enrollment of virtually all of our first wave of clinical studies for denosumab. Yes, question for Kevin, on denosumab. So, we do not see this as a, if you will, sort of normal general practitioner kind of sales product that just throw in the bag. Short Westwood Holdings Why Valuation Matters.

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